Several studies focus on the effects of climate variability on female and male gender relations as perceived through various biophysical and socio-economic aspects. More emphasis is given on the impacts of extreme weather events on rural communities of less developed regions. The results are often interpreted in a qualitative manner through policy measures that may reduce gender inequalities. However, the interpretation of the qualitative results to more crisp and measurable outputs is often not attained while the validation of the findings is rarely ensured. The current study suggests a gender-differentiated impact framework based on qualitative and quantitative components for the assessment of climate variability effects on rural communities in South India. Fifteen villages mostly practicing rice farming in Andhra Pradesh and Telangana states were selected as representative drought-prone case studies. The study results advocate that the qualitative outcomes were validated from the quantitative approach but for a few cases which could be attributed to methodological and case-specific differentiations. Policy recommendations are made on common gender trainings in water-resistant crops and livestock activities for the alleviation of drought impact and abatement of gender inequalities. Also, entrepreneurship workshops for women could enhance gender balance and diverse family income from the current sole dependence on farming revenues. Regional climate adaptation programs could be better implemented when the specific features and capacities of local communities are taken into consideration.