Combination of Benznidazole and Nifurtimox plus Posaconazole enhances activity against Trypanosoma cruzi in experimental Chagas disease

Abstract

This study in experimentally infected mice showed that the combination of posaconazole and benznidazole or nifurtimox was significantly more efficacious against Trypanosoma cruzi than the same dose of each drug alone, although there is a need for confirmation of the findings in experimental models with prolonged exposure and immunosuppression for assessment of cure. It is suggested that alternative combination regimens for Chagas' disease should be further investigated