Recent progress in discovering new drugs: fexinidazole and other candidates in the pipeline

Abstract

A review of existing data on nitroimidazoles as part of efforts to find new drugs to treat human African trypanosomiasis revealed the possible suitability of fexinidazole, which had been in preclinical development by Hoechst in the 1980s as a broad-spectrum antiprotozoal agent but not developed further; it was studied further by DNDi. Information is provided about its pharmacokinetics, efficacy, safety and clinical development