Pathways to Resilience in Semi-Arid Economies (PRISE) is a five-year interdisciplinary and cross-regional research consortium that has generated new evidence on how economic development can be achieved in semi-arid regions in ways that are sustainable, equitable and resilient to climate change. PRISE achieved this by supporting and strengthening the commitment of decision-makers and economic actors in local, sub-national and national governments, trade bodies and businesses. Actors were supported to develop policy interventions and make investment decisions that mainstream climate change risks and adaptation options into core economic activities and development planning. PRISE adopted what it termed a ‘policy and development first’ approach by jointly formulating its research questions and study areas in collaboration with target stakeholders (in-country decision-makers) and framing them in relation to their knowledge needs and development priorities. Through research, consultation, dialogue and trust-building with stakeholders, PRISE produced a wealth of evidence to inform climate-resilient and equitable development pathways in dryland economies. This report summarises: the key thematic, national and global findings and policy recommendations; related engagement activities and stories of impact; the approach taken by the consortium and how it was set up and managed; the monitoring of outcomes; the lessons learned; and next steps for how the research findings and recommendations can be used to inform future programming and the climate adaptation and ‘leave no one behind’ agendas.