Scientific Publication

Assessing anti-T. cruzi candidates in vitro for sterile cidality

author(s) Cal, M. - loset, J.R.. - Fugi, M. - Masera, P. - Kaiser, M.
from UK Foreign, Commonwealth & Development Office (FCDO)
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Cal M, Ioset JR, Fügi M, Mäsera P, Kaiser M. (2016). Assessing anti-T. cruzi candidates in vitro for sterile cidality. International Journal for Parasitology: Drugs and Drug Resistance Volume 6, Issue 3, December 2016, Pages 165-170 https://doi.org/10.1016/j.ijpddr.2016.08.003

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Abstract

It seems to be important for new drug candidates for Chagas disease to totally clear the T. cruzi infection (sterile cure), thus ensuring long-term beneficial effects for patients in the chronic indeterminate stage avoiding relapse. The authors have adapted an in vitro system to predict the ability of a compound to deliver sterile cure. This research was primarily funded by the Drugs for Neglected Diseases (DNDi) initiative

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