Scientific Publication

A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites

author(s) Filali-Ansary, A. - Auge, C. - Abgrall, A. - Souchaud, M. - Pellissier, F.
from UK Foreign, Commonwealth & Development Office (FCDO)
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Filali-Ansary A, Augé C, Abgrall A, Souchaud M, Pellissier F, Valverde Mordt O, Blesson S, Sanderink JG. (2016) A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites. Bioanalysis, Vol. 8, No. 19 https://doi.org/10.4155/bio-2016-0110

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Abstract

Fexinidazole (FEX) is a nitroimidazole being developed as a new trypanocide treatment for human African trypanosomiasis/sleeping sickness. A specific, accurate and reproducible assay was developed for quantitation of FEX and its metabolites M1 and M2 in dried blood spots (DBS), collected via finger-prick from healthy subjects. DBS samples were stable for 24 h at 37°C with 95% relative humidity, and 58 weeks desiccated at room temperature, making DBS finger-prick sampling a simple, practical method for determining FEX, M1 and M2 concentrations in clinical studies in Africa. This research is part of the Drugs for Neglected Diseases initiative (DNDi)

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