Scientific Publication

Decreased protein C function predicts mortality in patients with cirrhosis

author(s) Patil, A.G.. - Bihari, C. - Shewade, H.D.. - Nigam, N. - Sarin, S.K.
from UK Foreign, Commonwealth & Development Office (FCDO)
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themes
regions
  • Northern Europe
  • Europe
  • World
  • Southern Asia
  • Asia
citation

Patil AG, Bihari C, Shewade HD, Nigam N, Sarin SK. Decreased protein C function predicts mortality in patients with cirrhosis. Int. J. Lab. Hematol. (Internet). 2018; Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.12836

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Abstract

Protein C (PrC), a physiological anticoagulant, regulates inflammation and cell death and has known predictive/therapeutic roles in sepsis. Accumulating evidences suggest plasma hypercoagulability results in progression of fibrosis and formation of microclots causing end‐organ dysfunction. We investigated a possible association between natural anticoagulants—PrC, protein S (PrS) and antithrombin III (AT)—and clinical outcomes in cirrhotics. This research was supported by the UK Department for International Development’s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)

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