Modular multiantigen T cell epitope–enriched DNA vaccine against human leishmaniasis

Abstract

The leishmaniases are protozoal diseases that severely affect large populations in tropical and subtropical regions. There are only limited treatment options and preventative measures. Vaccines will be important for prevention, control and elimination of leishmaniasis, and could reduce the transmission and burden of disease in endemic populations. The authors report the development of a DNA vaccine against leishmaniasis that induced T cell–based immunity and is a candidate for clinical trials