Pathogens associated with persistent diarrhoea in children in low and middle income countries: systematic review

Abstract

Persistent diarrhoea in children is a common problem in low and middle income countries. To help target appropriate treatment for specific pathogens in the absence of diagnostic tests, the authors systematically reviewed pathogens most commonly associated with persistent diarrhoea in children. It was concluded that a number of pathogens are commonly associated with persistent diarrhoea in children, but in children without diarrhoea the pathogens are found with similar frequencies. New research with carefully selected controls and standardised laboratory investigations across countries would help map causes and help explore effective options for presumptive treatment