Prevalence of hepatitis B and C serological markers among first-time blood donors in Brazil: a multi-center serosurvey

Abstract

Little data is available on the seroprevalence of, and risk factors for hepatitis B and C virus (HBV and HCV) infection in Latin American countries. A multi-center serosurvey was conducted among 3598 first-time blood donors (65% men) from Sao Paulo, Salvador and Manaus in Brazil. The gender-specific seroprevalences of antibodies against hepatitis B core antigen (anti-HBc) and of the hepatitis B surface antigen (HBsAg) in anti-HBc-positive sera were measured, and risk factors analyzed by gender. The gender-specific seroprevalences of antibodies against HCV (anti-HCV) were measured, but risk factors for HCV were not determined. Anti-HBc and HBsAg seroprevalences were not significantly different in men (101/2341 (4.31%) and 4/2229 (0.18%), respectively) and women (65/237 (5.25%) and 8/1,169 (0.68%), respectively), whereas the seroprevalence of anti-HCV was higher in women (12/1238 (0.97%) vs. 9/2353 (0.38%); odds ratio (OR) = 2.49; 95% confidence interval (CI): 1.0-6.0). No significant difference for HBV infection was found across the three study sites or by ethnic group. The seroprevalence of anti-HBc increased with age, but decreased with education level in both genders. Lifetime number of sexual partners was associated with anti-HBc prevalence among men (OR = 1.95; 95% CI: 1.2-3.1), but not women. The seroprevalence of HBV and HCV was low among Brazilian blood donors, and exposure increased with age in both genders